Levodopa + carbidopa 10:1

Generic name
Levodopa + carbidopa 10:1
Brand name
ATC Code
N04BA02
Compare …

Levodopa + carbidopa 10:1

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

GTP cyclohydrolase I deficiency (GTPCH); 6 pyruvoyl tetrahydropterin synthase deficiency (PTPS); dihydropteridine reductase deficiency (DHPR)
  • Oral
    • Term neonate
      • Levodopa:carbidopa = 10:1
        Dose according to the levodopa:
         1 - 3         mg/kg/day in 3 - 6 doses. Increase gradually over a few days/weeks in steps of no more than 1 mg/kg..

      • Treatment by or after consultations with a paediatric specialist (metabolic disorders) who has experience using levodopa-carbidopa for this indication.

    • 1 month up to 2 years
      • Levodopa:carbidopa = 10:1
        Dose according to the levodopa: 4 - 7         mg/kg/day in 3 - 6 doses. Increase gradually over a few days/weeks in steps of no more than 1 mg/kg per day/week.

      • Treatment by or after consultations with a paediatric specialist (metabolic disorders) who has experience using levodopa-carbidopa for this indication.

    • ≥ 2 years
      • Levodopa:carbidopa = 10:1
        Dose according to the levodopa 8 - 15         mg/kg/day in 3 - 6 doses. Increase gradually over a few days/weeks in steps of no more than 1 mg/kg per day/week..

      • Treatment by or after consultations with a paediatric specialist (metabolic disorders) who has experience using levodopa-carbidopa for this indication.
Tyrosine hydroxylase deficiency
  • Oral
    • 0 years up to 18 years
      • Dose according to the levodopa: 1 - 10 mg/kg/day in 2 - 6 doses. . Increase gradually over a few days/weeks in steps of no more than 1 mg/kg..

      • Use the 25% product (levodopa:carbidopa 4:1) when the total daily dose of levodopa is less than 400 mg, use the 10% product (levodopa:carbidopa 10:1) otherwise.

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

DOPAMINERGIC AGENTS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Reference

  1. Blau, Hoffmann, Leonard and Clarke, Physicians guide to the treatment and follow-up of metabolic diseases., Springer, 2006

Changes

Therapeutic Drug Monitoring


Overdose