Phenoxymethylpenicillin-Benzathin
Generic name
Phenoxymethylpenicillin-Benzathin
Brand name
ATC Code
J01CE10
- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
Die Serumhalbwertszeit beträgt nach Gabe von Phenoxymethylpenicillin-Benzathin 2,5 Stunden (Phenoxymethylpenicillin-Kalium 30–45 Minuten). Aufgrund der verlängerten Halbwertszeit ist Phenoxymethylpenicillin-Benzathin für eine 2 x tägliche Dosierung geeignet.
Phenoxymethylpenicillin-Benzathin zeigt im Vergleich zu einem herkömmlichen Präparat mit Phenoxymethylpenicillin-Kalium bei gleich guter Bioverfügbarkeit eine langsamere Resorption und erheblich verzögerte Elimination des Wirkstoffes Phenoxymethylpenicillin.
Im Einzelnen wurden folgende pharmakokinetische Parameter ermittelt:
| Tmax (h) | AUC (h x mg/l) | T1/2 (h) | |
| Phenoxymethylpenicillin-Benzathin | 1,23 | 2,5 | 2,3 |
| Phenoxymethypenicillin-Kalium | 0,38 | 4,8 | 0,75 |
dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
Available formulations
No information is present at this moment.
Dosages
Renal impaiment in children > 3 months
No information available on dose adjustment in renal impairment.
The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects
No information is present at this moment.
The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions
No information available on specific warnings and precautions in children.
Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
BETA-LACTAM ANTIBACTERIALS, PENICILLINS
This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.
| Penicillins with extended spectrum | ||
|---|---|---|
| J01CA04 | ||
| J01CA01 | ||
| J01CA11 | ||
| J01CA08 | ||
| Beta-lactamase sensitive penicillins | ||
|---|---|---|
| J01CE08 | ||
| J01CE01 | ||
| J01CE05 | ||
| J01CE02 | ||
| Beta-lactamase resistant penicillins | ||
|---|---|---|
| J01CF01 | ||
| J01CF05 | ||
| J01CF02 | ||
| J01CF02 | ||
| Combinations of penicillins, incl. beta-lactamase inhibitors | ||
|---|---|---|
| J01CR02 | ||
| J01CR01, J01CR04 | ||
| J01CR05 | ||
| J01CR04 | ||
References
Changes
Therapeutic Drug Monitoring
Overdose
