Nelarabine

Generic name
Nelarabine
Brand name
ATC Code
L01BB07
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Nelarabine

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

Paediatric patients:

  Dose Nelarabin ara - G 
Cmax - Plasma 650 mg/m2 45.0 µM 60.1 µM
Vd 104 - 2,900 mg/m2 89.4 L/m2 32.1 L/m2
T1/2 650 mg/m2 30 min 3 h
Cl 104 - 2,900 mg/m2 125 L/h/m2 10.8 L/h/m2

[SmPC Atriance]

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

T-ALL, T-LBL
  • Intravenous
    • < 16 years
      • 650 mg/m²/day in 1 dose run in over 1 hour for 5 consecutive days in a cycle of 21 days..
    • 16 years up to 21 years
      • 650 - 1.500 mg/m²/day in 1 dose

      • 650 mg/m²: run in over 1 hour for 5 consecutive days in a cycle of 21 days.
        1500 mg/m²: run in over 2 hours on days 1, 3 and 5 in a cycle of 21 days

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

One fatal case of status epilepticus was reported in a child.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

ANTIMETABOLITES

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Purine analogues
L01BB06
L01BB05
L01BB02
L01BB03
Pyrimidine analogues
L01BC01
L01BC52
L01BC05

Reference

  1. Sandoz Pharmaceuticals d.d, SmPC Atriance (EU/1/07/403/001) Rev 28, 13-05-2024, www.ema.europa.eu

Changes

Therapeutic Drug Monitoring


Overdose