Mercaptopurine

Generic name
Mercaptopurine
Brand name
ATC Code
L01BB02
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Mercaptopurine

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Inflammatory bowel disease (IBD)
  • Oral
    • 1 month up to 18 years
      • 1 - 1.5 mg/kg/day in 1 dose
Oncological conditions
  • Oral
    • 0 years up to 18 years

      • Achtung:
        Dosis und Dosisfrequenz von Zytostatika hängen von der Erkrankung ab und sind stark neuen Erkenntnissen unterworfen. Zytostatika werden in der Onkologie/Hämatologie oftmals in Kombination verwendet. Aus diesem Grunde wird auf die detaillierten Behandlungsprotokolle verwiesen.

        Als Hinweis wird folgende Dosierung des Herstellers angeführt: 2,5 mg/kg/Tag oder 50-75 mg/m2/Tag

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

Hypoglycaemia (especially with low BMI or children <6 years).

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

ANTIMETABOLITES

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Purine analogues
L01BB06
L01BB05
L01BB07
L01BB03
Pyrimidine analogues
L01BC01
L01BC52
L01BC05

References

  1. Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
  2. Turner D, et al., Management of pediatric ulcerative colitis: joint ECCO and ESPGHAN Evidence-Based Consensus Guidelines, JPGN, 2012, 55(3), 340-61
  3. GlaxoSmithKline BV, SPC Puri-Nethol (RVG 00589) 13-2-2019, www.cbg-meb.nl
  4. Nova, SmPC Xaluprine 20mg/ml Suspension zum Einnehmen (EU/1/11/727/001), 07/2017
  5. MEDICE, SmPC Mercaptopurin 10mg Tabletten (64742.00.00), 10/2017
  6. Aspen, SmPC Puri-Nethol 50mg Tabletten (6102083.00.00), 09/2017
  7. Informatorium Medicamentorum., (Interacties), Geraadpleegd 16 aug 2018
  8. Nova, SmPC Xaluprine 20mg/ml Suspension zum Einnehmen (EU/1/11/727/001), 07/2017
  9. Wine E. et al., Management of paediatric ulcerative colitis, part 1: Ambulatory care-An updated evidence-based consensus guideline from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition and the European Crohn's and Colitis Organisation, JPGN, 2025, 81(3), 765-815

Changes

Therapeutic Drug Monitoring


Overdose