Nicardipine

Generic name
Nicardipine
Brand name
ATC Code
C08CA04
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Nicardipine

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Hypertensive crisis
  • Intravenous
    • 1 month up to 18 years
      • Initial dose: 15 microg./kg/dose, bolus in 10 minutes.
      • Maintenance dose: 0.5 - 3 microg./kg/minute, continuous infusion.

      • With continuous monitoring of the blood pressure.
Acute hypertension
  • Intravenous
    • Term neonate
      • 0.5 - 2 microg./kg/minute, continuous infusion.

      • With continuous monitoring of the blood pressure.

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Consult a nephrologist: experience in children is very limited. Be aware of the possibility of reflex tachycardia.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Dihydropyridine derivatives
C08CA01
C08CA05

References

  1. Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
  2. Heijden, van der AJ et al, Werkboek Kindernefrologie, VU Uitgeverij, 2002, 1e druk
  3. Lurbe E, et al, Management of high blood pressure in children and adolescents: recommendations of the European Society of Hypertension, J Hypertens, 2009, Sep;27(9), 1719-42
  4. Mastropietro CW et al., Nicardipine for Hypertension Following Aortic Coarctectomy or Superior Cavopulmonary Anastomosis, World J Pediatr Congenit Heart Surg., 2016, Jan;7(1), 32-5
  5. Liviskie CJ, et al., Nicardipine for the treatment of neonatal hypertension during extracorpeal membrane oxygenation, Pediatr Cardiol, 2019, 40, 1041-5

Changes

Therapeutic Drug Monitoring


Overdose