Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Amphotericin B lipid complex

Generic name
Amphotericin B lipid complex
Brand name
ATC Code
J02AA01

Pharmacokinetics in children

No information

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

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Available formulations

No information is present at this moment.

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Dosages

Systemic mycoses
  • Intravenous
    • Term neonate
      • 2.5 - 5 mg/kg/day in 1 dose
    • 1 month up to 18 years
      • 3 - 5.5 mg/kg/day in 1 dose The maximum cumulative dose is 10 g
        (NOTE: THE CALCULATOR DOES NOT CHECK THE CUMULATIVE DOSE!).
      • The manufacturer of Abelcet recommends a test dose of 0.1 mg/kg and a maximum of 1 mg. There is no scientific foundation for this. It also does not give a reliable prediction for the tolerance.

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Renal impaiment in children > 3 months

Adjustment in renal impairment as specified:

GFR 50-80 ml/min/1.73 m2
Adjustment not necessary.
GFR 30-50 ml/min/1.73 m2
Adjustment not necessary.
GFR 10-30 ml/min/1.73 m2
Adjustment not necessary.
GFR < 10 ml/min/1.73 m2
No generalized dose recommendations are given

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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References

  1. Hartwig NC, et al, Vademecum pediatrische antimicrobiele therapie, 2005
  2. Cephalon Ltd., SPC Abelcet (RVG 20850) 17-09-2018, www.geneesmiddeleninformatiebank.nl
  3. Pane ZD et al., Therapeutic strategies for invasive fungal infections in neonatal and pediatric patients: an update., Expert Opin Pharmacother, 2015, Apr;16(5), 693-10

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Changes

Changes