Dexamethasone + framycetin + gramicidin (combination preparation)
Generic name
Dexamethasone + framycetin + gramicidin (combination preparation)
Brand name
ATC Code
S02CA06
- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
No information
dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
Available formulations
No information is present at this moment.
Dosages
| Chronic recurrent middle ear inflammation with otorrhoea |
|---|
|
Renal impaiment in children > 3 months
No information available on dose adjustment in renal impairment.
The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects
No information is present at this moment.
The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions in children
The use of topical agents when the middle ear is open involves a (mild) risk of ototoxicity leading to high-frequency hearing loss and vestibulotoxicity that can cause balance problems. Ototoxicity is very rare in clinical settings, estimated at 0.01-0.03%, and is clearly less common than perceptual hearing loss due to a chronically secreting middle ear inflammation. Swollen middle ear mucosa as a result of chronically secreting middle ear inflammation also protects the middle ear against the ototoxic components of the ear drops. Long-term use in children can lead to the suppression of the production of adrenal cortex hormones.
Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.
| Corticosteroids and antiinfectives in combination | ||
|---|---|---|
| S02CA03 | ||
| S02CA03 | ||
| S02CA07 | ||
| S02CA07 | ||
| S02CA03 | ||
| S02CA03 | ||
| S02CA04 | ||
References
- Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
- Mylanus E.A.M. et al, Standpunt nota \"Gebruik van oordruppels bij otitis media met trommelvliesperforatie en in operatieholtes\", Nederlandse Vereniging voor KNO en heelkunde van het hoofdhals gebied, 2006
- Sanofi Aventis Netherlands BV, SPC Sofradex (RVG 04961) 09-02-2015, www.geneesmiddeleninformatiebank.nl
Changes
Therapeutic Drug Monitoring
Overdose
