- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
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Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
No pharmacokinetic studies have been carried out in children.
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
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Available formulations
No information is present at this moment.
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Dosages
| Bacterial infections |
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| Severe acne vulgaris |
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Renal impaiment in children > 3 months
GFR ≥10 ml/min/1.73m2: Dose adjustment not required.
GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects in children
Gastrointestinal disorders such as nausea, vomiting, diarrhoea, rare cases of pseudomembranous colitis and staphylococcal enteritis, negative effects on bones and teeth in children. Intracranial hypertension [Fraser 2012]. Rhabdomyolysis has been described in a case report [Kempeneers 2013].
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications in children
Children younger than 8 years
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions in children
Treatment of children aged 8–12 years should only be considered when other options are ineffective or contraindicated. Crossover sensitivity and crossover resistance can occur between tetracyclines. Deposition in growing tooth tissue causes permanent discoloration of the teeth.
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| Tetracyclines | ||
|---|---|---|
| J01AA02 | ||
| J01AA07 | ||
| J01AA12 | ||
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References
- Merck BV, SPC Aknemin, RVG 18030, (Geraadpleegd 14 jan 10), www.cbg-meb.nl, http://db.cbg-meb.nl/IB-teksten/h18030-h18031.pdf
- Mylan, SPC Minocycline (RVG 22153), www.cbg-meb.nl, http://db.cbg-meb.nl/IB-teksten/h22153.pdf
- Fraser CL et al. , Minocycline-induced fulminant intracranial hypertension. , Arch Neurol. , 2012 , Aug;69(8):, 1067-70
- Garner SE et al., Minocycline for acne vulgaris: efficacy and safety., Cochrane Database Syst Rev., 2012, Aug 15;(8):, CD002086
- Kempeneers D et al., Rabdomyolyse op zowel isotretinoïne als minocycline in de behandeling van acne vulgaris bij een 15-jarige jongen, Ned Tijdschr. Derm. Venereol., 2013, Mei; 23(5), 275-277
- Dermapharm, SmPC Udima 50 mg Kps. (1-20149), https://www.univadis.at/, 05/2018
- Aurobindo, SmPC Minocycline (RVG 22098) 09-11-2018, www.geneesmiddelinformatiebank.nl
- Fraser CL et al., Minocycline-induced fulminant intracranial hypertension., Arch Neurol., 2012, Aug;69(8):, 1067-70
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Changes
Changes
