Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Formoterol

Generic name
Formoterol
Brand name
ATC Code
R03AC13

Pharmacokinetics in children

No information

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

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Available formulations

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Dosages

Maintenance treatment for asthma
  • Inhalation
    • 6 years up to 18 years
      • (Formoterolfumaratemonohydrate) 12 - 24 microg./day in 1 - 2 doses. Max: 48 microg./day.
      • Up to 24 mcg twice daily in severe asthma.
        Formoterol should always be prescribed in combination with an inhalation corticosteroid


        FORMULATIONS
        4-7 yrs: dosing aerosol + holding chamber with a mouthpiece.
        ≥ 7 yrs: dosing aerosol. Option: Dry powder inhaler (Diskus).

Acute asthma attack
  • Inhalation
    • 1 month up to 18 years
      • (Formoterolfumaratemonohydrate) 12 microg./dose, as required, max. 4 times daily.
      • NOTE: This is a temporary dosing recommendation to provide an alternative to salbutamol deficiency. There limited data on the use in children under 6 years of age.

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Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

Central nervous system stimulation effects, expressed as overstimulation and hyperactivity, have been reported sporadically after inhalation of β2-sympathomimetics. These effects have primarily been seen in children younger than 12

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Before prescribing formoterol, a bronchodilatory response should be confirmed by making an FEV1 measurement before and after beta-2 mimetics. An alternative to the lung function measurements in children aged less than 6 years is a good response to a LABA or SABA that has been administered. There is insufficient data known about the use of formoterol in children aged under 6 years.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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References

  1. AstraZeneca BV, SmPC Oxis (RVG 21026) 12-03-2024, www.geneesmiddeleninformatiebank.nl
  2. NVK, Richtlijn Astma bij Kinderen, 2013

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Changes

Changes