- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
After subcutaneous administration of 150 mg every 4 weeks (2 to 6 years) and 150 mg every 2 weeks (6 to 12 years), overall exposure (i.e. Cavg,ss) to lanadelumab was similar in adult and adolescent (12 to 18 years) patients.
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
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Available formulations
No information is present at this moment.
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Dosages
| Routine prevention of angio-oedema episodes |
|---|
|
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Renal impaiment in children > 3 months
GFR ≥10 ml/min/1.73m2: Dose adjustment not required.
GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects in children
The side effect profile in children does not differ from that in adults.
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions
No information available on specific warnings and precautions in children.
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| Enzymes | ||
|---|---|---|
| B06AA03 | ||
| Drugs used in hereditary angioedema | ||
|---|---|---|
| B06AC04 | ||
| B06AC02 | ||
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References
- Takeda Pharmaceuticals International AG Ireland Branch , SmPC Takhzyro (EU EU/1/18/1340/001) Rev 12; 22-11-2023 , www.ema.europa.eu
- Takeda Pharmaceuticals International AG Ireland Branch, SmPC Takhzyro (EU EU/1/18/1340/001) Rev 12; 22-11-2023, www.ema.europa.eu
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Changes
Changes
