Oxazepam

Generic name
Oxazepam
Brand name
ATC Code
N05BA04
Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No scientific studies have been conducted into the pharmacokinetics of oxazepam in children.

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Pathological anxiety and tension
  • Oral
    • < 6 years
      • 10 - 30 mg/day in 3 - 4 doses.

      • No studies have been carried out in children. The manufacturer assumes that the dosage for children has been extrapolated from the adult dose.

    • 6 years up to 12 years
      • 10 - 40 mg/day in 3 - 4 doses.

      • No studies have been carried out in children. The manufacturer assumes that the dosage for children has been extrapolated from the adult dose.

    • 12 years up to 18 years
      • 30 - 40 mg/day in 3 - 4 doses. Max: 80 mg/day.

      • No studies have been carried out in children. The manufacturer assumes that the dosage for children has been extrapolated from the adult dose.

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

Sedation, concentration/memory problems, tolerance/dependency (in longer-term use). Particularly at high doses, in children: paradoxical reactions such as acute excitement and changes in the mental condition. Rare: disinhibition (paradoxical reaction).

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

When used in child and youth psychiatry: The indications for prescribing benzodiazepines are very limited. In practice, the drugs may be used briefly for acute anxiety and sudden extreme insomnia.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

ANXIOLYTICS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Benzodiazepine derivatives
N05BA12
N05BA08
N05BA09
N05BA01
N05BA06
Diphenylmethane derivatives
N05BB01
Azaspirodecanedione derivatives
N05BE01

Reference

  1. Centrafarm BV, SPC Oxazepam (RVG 055928), www.cbg-meb.nl, Geraadpleegd 01 april 2011

Changes

Therapeutic Drug Monitoring


Overdose