Paracetamol + caffeine

Generic name
Paracetamol + caffeine
Brand name
ATC Code
N02BE51
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Paracetamol + caffeine

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

In adults, paracetamol is conjugated in the liver with glucuronic acid (approx. 60%), sulphate (approx. 35%) and cysteine (approx. 3%). In neonates and children up to 12 years of age, sulphate conjugation is the predominant elimination pathway and glucuronidation occurs to a lesser extent than in adults. However, the total elimination in children as a result of the increased sulphation capacity is broadly comparable to that of adults.

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Mild pain and fever
  • Oral
    • 6 years up to 9 years

      • Paracetamol/caffeine: 250 mg/25 mg 4-6 times daily

    • 9 years up to 12 years

      • Paracetamol/caffeine 500 mg/50 mg 3-4 times daily

    • 12 years up to 15 years

      • Paracetamol/caffeine 500 mg/50 mg 4-6 times daily

    • ≥ 15 years

      • Paracetamol/caffeine 500-1000 mg/50-100 mg, maximum 3000 mg/300 mg per day

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

OTHER ANALGESICS AND ANTIPYRETICS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Anilides
N02BE01
Gabapentinoids
N02BF01

References

  1. Pharmachemie BV, SmPC Paracetamol/coffeine (RVG 55045) 13-03-2015, www.geneesmiddeleninformatiebank.nl
  2. Bayer BV, SmPC Finimal (RVG 06448) 15-10-2018, www.geneesmiddeleninformatiebank.nl

Changes

Therapeutic Drug Monitoring


Overdose