- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
In adults, paracetamol is conjugated in the liver with glucuronic acid (approx. 60%), sulphate (approx. 35%) and cysteine (approx. 3%). In neonates and children up to 12 years of age, sulphate conjugation is the predominant elimination pathway and glucuronidation occurs to a lesser extent than in adults. However, the total elimination in children as a result of the increased sulphation capacity is broadly comparable to that of adults.
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
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Available formulations
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Dosages
| Mild pain and fever |
|---|
|
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Renal impaiment in children > 3 months
GFR ≥10 ml/min/1.73m2: Dose adjustment not required.
GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects
No information is present at this moment.
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions
No information available on specific warnings and precautions in children.
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| Anilides | ||
|---|---|---|
| N02BE01 | ||
| Gabapentinoids | ||
|---|---|---|
| N02BF01 | ||
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References
- Pharmachemie BV, SmPC Paracetamol/coffeine (RVG 55045) 13-03-2015, www.geneesmiddeleninformatiebank.nl
- Bayer BV, SmPC Finimal (RVG 06448) 15-10-2018, www.geneesmiddeleninformatiebank.nl
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Changes
Changes
