Methylthionine (methylene blue)
Generic name
Methylthionine (methylene blue)
Brand name
ATC Code
V03AB17
- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
No information
dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
Available formulations
No information is present at this moment.
Dosages
| Aniline or dapsone-induced methaemoglobinaemia |
|---|
|
Renal impaiment in children > 3 months
- eGFR 60-89 ml/min/1.73m2: dose adjustment not required
- eGFR 30-59 ml/min/1.73m2: 1-2 mg/kg/dose. Repeat if necessary. Maximum cumulative dose: 2 mg/kg/day
- eGFR 15-29 ml/min/1.73m2: single dose of 1 mg/kg/dose. Maximum cumulative dose: 1 mg/kg/day
Infants < 3 months:
- eGFR 15-59 ml/min/1.73m2: use with caution, as no data are available and methylthioninium chloride is excreted primarily renally. Lower maximum cumulative doses (< 0.5 mg/kg body weight) may be considered.
The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects in children
The side effects in children are similar to those in adults. Hyperbilirubinaemia is reported in infants.
The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions in children
Can cause haemolysis. Children younger than 3 months have lower levels of NADPH-methaemoglobin reductase, making them more susceptible to methaemoglobinaemia caused by high doses of methylthionine.
Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
ALL OTHER THERAPEUTIC PRODUCTS
This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.
| Antidotes | ||
|---|---|---|
| V03AB27 | ||
| V03AB16 | ||
| V03AB24 | ||
| V03AB25 | ||
| V03AB33 | ||
| V03AB15 | ||
| V03AB13 | ||
| V03AB19 | ||
| V03AB14 | ||
| V03AB06 | ||
| V03AB35 | ||
| Iron chelating agents | ||
|---|---|---|
| V03AC03 | ||
| V03AC02 | ||
| V03AC01 | ||
| Drugs for treatment of hyperkalemia and hyperphosphatemia | ||
|---|---|---|
| V03AE07 | ||
| V03AE01 | ||
| V03AE02 | ||
| V03AE01 | ||
| Detoxifying agents for antineoplastic treatment | ||
|---|---|---|
| V03AF03 | ||
| V03AF01 | ||
| V03AF07 | ||
| Drugs for treatment of hypoglycemia | ||
|---|---|---|
| V03AH01 | ||
| Other therapeutic products | ||
|---|---|---|
| V03AX03 | ||
| DETOXIFYING AGENTS FOR ANTINEOPLASTIC TREATMENT | ||
|---|---|---|
| V03AF03 | ||
| V03AF01 | ||
| V03AF07 | ||
| OTHER THERAPEUTIC PRODUCTS | ||
|---|---|---|
| V03AX03 | ||
References
- Driscoll W, et al, Effect of methylene blue on refractory neonatal hypotension, J Pediatr, 1996, Dec;129(6), 904-8
- PROVEPHARM SAS, SmPC Methylthionine Proveblue (EU/1/11/682) REV 25; 15-12-2022, https://www.ema.europa.eu
Changes
Therapeutic Drug Monitoring
Overdose
