Salmeterol

Generic name
Salmeterol
Brand name
ATC Code
R03AC12

Salmeterol

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Bronchial dilation (long-acting)
  • Inhalation
    • Aerosol
      • 4 years up to 18 years
        • 50 - 100 microg./day in 2 doses. in combination with inhalation corticosteroids..
        • Do not use as a treatment for attacks.

          Administration: dosing aerosol with a holding chamber with a mouthpiece.

    • Inhalation powder
      • 7 years up to 18 years
        • 50 - 100 microg./day in 2 doses. in combination with inhalation corticosteroids.
        • Do not use as a treatment for attacks.

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

There is insufficient data known about the use of salmeterol in children aged under 4 years. Before prescribing salmeterol, a bronchodilating response should be confirmed and documented by making an FEV1 measurement before and after beta-2 mimetics. An alternative to the lung function measurements in children aged less than 6 years is a good clinical response to a short-acting beta-2-agonist. Use of long-acting beta-2-agonist should be prescribed in the secondary care sector as per the guidelines of the NHG (Dutch College of General Practitioners) and the SKL (Paediatric Pulmonary Disease Section).
Do not use as treatment for acute asthma attacks.
Administration: Serevent dosing aerosol can be administered in combination with the following holding chambers: Volumatic (age > 4 years)

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

ADRENERGICS, INHALANTS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Alpha- and beta-adrenoreceptor agonists
R03AA01
Selective beta-2-adrenoreceptor agonists
R03AC13
R03AC02
R03AC03
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
R03AK08
R03AK11
R03AK10
R03AK07
R03AK06
Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids
R03AL01
R03AL02

References

  1. NVK sectie Kinderlongziekten, Medicamenteuze behandeling van astma bij kinderen. Herziene richtlijnen van kinderlongartsen, 2007
  2. GlaxoSmithKline BV, SPC Serevent aerosol (RVG 33735), www.cbg-meb.nl, Geraadpleegd 27 oktober 2010, http://db.cbg-meb.nl/IB-teksten/h33735.pdf

Changes

Therapeutic Drug Monitoring


Overdose