Chlorhexidine (local, in the mouth)

Generic name
Chlorhexidine (local, in the mouth)
Brand name
ATC Code
A01AB03
Compare …

Chlorhexidine (local, in the mouth)

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Severe mucositis during chemotherapy and irradiation
  • Dental
    • < 5 years

      • 4-6x daily ‘brush’ or spray (10 puffs) with 0.2% chlorhexidine solution

        Alternative: spray 10 ml of the 0.2% solution using a Ritter spray on a compressed air connection

    • ≥ 5 years

      • Rinse 4-6x daily with 10 ml 0.2% solution (do not swallow!) OR 10 puffs of 0.2% chlorhexidine spray 4-6x daily


        Alternative: spray with 10 ml of 0.2% solution using a Ritter spray on a compressed air connection

    • < 5 years

      • 4-6x daily ‘brush’ or spray (10 puffs) with 0.2% chlorhexidine solution

        Alternative: spray 10 ml of the 0.2% solution using a Ritter spray on a compressed air connection

    • ≥ 5 years

      • Rinse 4-6x daily with 10 ml 0.2% solution (do not swallow!) OR 10 puffs of 0.2% chlorhexidine spray 4-6x daily


        Alternative: spray with 10 ml of 0.2% solution using a Ritter spray on a compressed air connection

Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Chlorhexidine must not be swallowed. In young children aged (< 5 years), apply the fluid using brushes.

Chlorhexidine solution must not be mixed with physiological saline, because that significantly reduces the effect. The drug has a bitter taste and often causes brown discolouration of teeth (incl. molars). The latter effect is amplified by toothpaste that contains fluoride and orally administered antibiotics, in particular amoxicillin suspension. The toothpastes Elmex® and Zendium® do not contain sodium lauryl sulphate and can be used together with chlorhexidine. After the treatment, the discolouration can be removed by polishing the teeth. In local treatment with nystatin, the treatments with chlorhexidine and nystatin should be at least 30 minutes apart.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

STOMATOLOGICAL PREPARATIONS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Caries prophylactic agents
A01AA01

References

  1. GlaxoSmithKline Consumer Health BV, SPC Corsodyl (RVG 09822), www.cbg-meb.nl, Geraadpleegd 17 aug 2011, http://db.cbg-meb.nl/IB-teksten/h09822.pdf
  2. Kamps WA et al, Werkboek ondersteunende behandeling in de kinderoncologie, www.nvk.nl (alleen leden), 2005

Changes

Therapeutic Drug Monitoring


Overdose