Pharmacokinetics in children
No information is present at this moment.
dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
Available formulations
No information is present at this moment.
Dosages
| Moderate to severe plaque psoriasis |
- Subcutaneous
-
≥ 6 years
and
<
50 kg
- Initial dose:
75
mg/dose
once a week.
in week 0, 1, 2, 3 and 4..
- Maintenance dose:
75
mg/dose
once a month.
-
≥ 6 years
and
≥ 50 kg
|
| Juvenile idiopathic arthritis (JIA) |
- Subcutaneous
-
≥ 6 years
and
<
50 kg
- Initial dose:
75
mg/dose
once a week.
in week 0, 1, 2, 3 and 4..
- Maintenance dose:
75
mg/dose
once a month.
-
≥ 6 years
and
≥ 50 kg
- Initial dose:
150
mg/dose
once a week.
in week 0, 1, 2, 3 and 4.
- Maintenance dose:
150
mg/dose
once a month.
|
Renal impaiment in children > 3 months
No information available on dose adjustment in renal impairment.
The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects in children
The safety profile in children does not differ from that in adult patients.
The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions in children
Before starting treatment, give children all age-appropriate immunizations in line with guidelines. Inactivated or non-live vaccines may be co-administered.
Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
IMMUNOSUPPRESSANTS
This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.
| Selective immunosuppressants |
|
|
|
L04AA24
|
|
|
|
L04AA32
|
|
|
|
L04AA13
|
|
|
|
L04AA02
|
|
|
|
L04AA06
|
|
|
|
L04AA31
|
|
|
|
L04AA04
|
|
|
|
L04AA44
|
| Other immunosuppressants |
|
|
|
L04AX01
|
|
|
|
L04AX03
|
| Tumor necrosis factor alpha (TNF-alpha) inhibitors |
|
|
|
L04AB04
|
|
|
|
L04AB01
|
|
|
|
L04AB06
|
|
|
|
L04AB02
|
| Interleukin inhibitors |
|
|
|
L04AC03
|
|
|
|
L04AC02
|
|
|
|
L04AC08
|
|
|
|
L04AC13
|
|
|
|
L04AC19
|
|
|
|
L04AC22
|
|
|
|
L04AC07
|
|
|
|
L04AC05
|
| Calcineurin inhibitors |
|
|
|
L04AD01
|
|
|
|
L04AD02
|
| Sphingosine-1-phosphate (S1P) receptor modulators |
|
|
|
L04AE01
|
| Janus-associated kinase (JAK) inhibitors |
|
|
|
L04AF02
|
|
|
|
L04AF02
|
|
|
|
L04AF08
|
|
|
|
L04AF01
|
| Monoclonal antibodies |
|
|
|
L04AG04
|
| Mammalian target of rapamycin (mTOR) kinase inhibitors |
|
|
|
L04AH02
|
|
|
|
L04AH01
|
| Complement inhibitors |
|
|
|
L04AJ01
|
|
|
|
L04AJ02
|
| Dihydroorotate dehydrogenase (DHODH) inhibitors |
|
|
|
L04AK02
|
Reference
-
Novartis Europharm Limited, SmPC Cosentyx (EU 1/14/980/001) Rev 30, 02-02-2023, www.ema.europa.eu
Therapeutic Drug Monitoring
Overdose