Colchicine

Generic name
Colchicine
Brand name
ATC Code
M04AC01
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Colchicine

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Familial Mediterranean fever (FMF) prophylaxis
  • Oral
    • 1 month up to 5 years
      • 0.5 mg/day in 1 - 2 doses. increase step by step if necessary (0.25 mg per step) to a maximum of 2 mg/day..
    • 5 years up to 10 years
      • 1 mg/day in 1 - 2 doses. increase step by step if necessary (0.25 mg per step) to a maximum of 2 mg/day.
    • ≥ 10 years
      • 1.5 mg/day in 1 - 2 doses. increase step by step if necessary (0.25 mg per step) to a maximum of 2 mg/day.

Renal impaiment in children > 3 months

  • GFR ≥30: dosage adjustment is not necessary.
  • GFR 10-30: 50% of normal starting dose, adjustment of dosing interval is not needed
  • GFR <10: general advice is not given.
Clinical consequences

With impaired renal function, the risk of toxicity may be increased.

Clinical Effects:
First signs of toxicity are a burning sensation in the throat, nausea, abdominal cramps, and diarrhea. Colchicine should be discontinued immediately in this case.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

Toxic with severe side effects, both acute and chronic. Burning sensation in the throat, nausea, abdominal cramps and diarrhoea. Neuropathy can arise in long-term use.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Colchicine has small therapeutic window and therefore there is a risk of toxicity. Discontinue administration in case of toxic symptoms such as burning sensation in the throat, nausea, vomiting, abdominal pain and diarrhea.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

ANTIGOUT PREPARATIONS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Preparations inhibiting uric acid production
M04AA01

References

  1. Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
  2. Franssen MJAM et al, Werkboek Kinderreumatologie, VU Uitgeverij, 2008, 2e druk
  3. Aurobindo, SmPC Colchicine 0,5 mg tablet (RVG 102274) 20-05-2016, www.geneesmiddeleninformatiebank.nl
  4. NKFK Werkgroep nierfunctiestoornissen, Extrapolatie van KNMP risico analyse "Verminderde nierfunctie" voor volwassenen naar kinderen, 20 Dec 2021

Changes

Therapeutic Drug Monitoring


Overdose