Romiplostim

Generic name
Romiplostim
Brand name
ATC Code
B02BX04
Compare …

Romiplostim

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

The pharmacokinetic parameters of romiplostim vary widely in both children and adults and therefore have no predictive value.

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Immune thrombocytopenia
  • Subcutaneous
    • ≥ 1 year
      • Initial dose: 1 microg./kg/dose once a week. Max: 10 microg./kg/week. Titrate the dose depending on the thrombocyte count:
        < 50 × 109/liter: increase weekly by 1 mcg/kg
        > 150 x 109/liter: lower weekly by 1 mcg/kg
        > 250 x 109/liter: interrupt administration until the thrombocyte count has dropped to < 150 x 109/liter and then resume with the previous dose, lowered by 1 mcg/kg..

      • Exclusively on prescription by a paediatric haematologist

Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

VITAMIN K AND OTHER HEMOSTATICS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Vitamin K
B02BA01
Fibrinogen
B02BB01
Local hemostatics
B02BC30
Blood coagulation factors
B02BD08
B02BD04
B02BD02
B02BD01
Other systemic hemostatics
B02BX05
B02BX06
Blood coagulation factors
B02BD08
B02BD04
B02BD02
B02BD01

Reference

  1. Amgen Europe BV, SmPC Nplate (EU/1/08/497/005-008) 27-02-2018

Changes

Therapeutic Drug Monitoring


Overdose