Fenprocoumon

Generic name
Fenprocoumon
Brand name
ATC Code
B01AA04

Fenprocoumon

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Anticoagulation
  • Oral
    • < 1 year
      • Day 1: 0.2 mg/kg/day in 1 dosis
        Day 2: 0.15 mg/kg/day in 1 dosis
        Day 3: 0.1 mg/kg/day in 1 dosis
        Afterwards titrate based on INR

    • 1 year up to 5 years
      • Day 1: 0.15 mg/kg/day in 1 dosis
        Day 2: 0.1 mg/kg/day in 1 dosis
        Day 3: 0.05 mg/kg/day in 1 dosis
        Afterwards titrate based on INR

    • ≥ 5 years
      • Day 1: 0.1 mg/kg/day in 1 dosis, max 9 mg
        Day 2: 0.05 mg/kg/day in 1 dosis, max 6 mg
        Day 3: 0.025 mg/kg/day in 1 dosis, max 3 mg
        afterwards titrate based on INR

Renal impaiment in children > 3 months

Consider lowering the loading dose in cases of renal function disorder.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

ANTITHROMBOTIC AGENTS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Vitamin K antagonists
B01AA07
Heparin group
B01AB04
B01AB09
B01AB05
B01AB01
B01AB06
B01AB10
Platelet aggregation inhibitors excl. heparin
B01AC06
B01AC04
B01AC09
Enzymes
B01AD02
B01AD01
B01AD04
Direct thrombin inhibitors
B01AE07
Direct factor Xa inhibitors
B01AF02
B01AF01

References

  1. NVK. , Werkboek kinderhematologie. , http://www.hematologienederland.nl , 30 sept 2012
  2. Spoor N et al., Phenprocoumon and acenocoumarol treatment in paediatric patients, Thromb Haemost., 2012, Dec;108(6), 1238-41
  3. NVK, Diagnostiek en behandeling van veneuze trombo-embolie bij kinderen, www.nvk.nl, jan 2014
  4. Nederlandse Vereniging voor Kindergeneeskunde, sectie kinderhematologie, Richtlijn Diagnostiek en behandeling van veneuze trombo-embolische complicaties bij neonaten en kinderen tot 18 jaar, https://hematologienederland.nl/kwaliteit/werkboek-kinderhematologie/, 2020, Jan, Rev1
  5. NVK., Werkboek kinderhematologie., http://www.hematologienederland.nl, 30 sept 2012

Changes

Therapeutic Drug Monitoring


Overdose