Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Fenprocoumon

Generic name
Fenprocoumon
Brand name
ATC Code
B01AA04

Pharmacokinetics in children

No information

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

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Available formulations

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Dosages

Anticoagulation
  • Oral
    • < 1 year
      • Day 1: 0.2 mg/kg/day in 1 dosis
        Day 2: 0.15 mg/kg/day in 1 dosis
        Day 3: 0.1 mg/kg/day in 1 dosis
        Afterwards titrate based on INR

    • 1 year up to 5 years
      • Day 1: 0.15 mg/kg/day in 1 dosis
        Day 2: 0.1 mg/kg/day in 1 dosis
        Day 3: 0.05 mg/kg/day in 1 dosis
        Afterwards titrate based on INR

    • ≥ 5 years
      • Day 1: 0.1 mg/kg/day in 1 dosis, max 9 mg
        Day 2: 0.05 mg/kg/day in 1 dosis, max 6 mg
        Day 3: 0.025 mg/kg/day in 1 dosis, max 3 mg
        afterwards titrate based on INR

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Renal impaiment in children > 3 months

Consider lowering the loading dose in cases of renal function disorder.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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References

  1. NVK. , Werkboek kinderhematologie. , http://www.hematologienederland.nl , 30 sept 2012
  2. Spoor N et al., Phenprocoumon and acenocoumarol treatment in paediatric patients, Thromb Haemost., 2012, Dec;108(6), 1238-41
  3. NVK, Diagnostiek en behandeling van veneuze trombo-embolie bij kinderen, www.nvk.nl, jan 2014
  4. Nederlandse Vereniging voor Kindergeneeskunde, sectie kinderhematologie, Richtlijn Diagnostiek en behandeling van veneuze trombo-embolische complicaties bij neonaten en kinderen tot 18 jaar, https://hematologienederland.nl/kwaliteit/werkboek-kinderhematologie/, 2020, Jan, Rev1
  5. NVK., Werkboek kinderhematologie., http://www.hematologienederland.nl, 30 sept 2012

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Changes

Changes