Sodium picosulphate + magnesiumoxide + citric acid

Generic name
Sodium picosulphate + magnesiumoxide + citric acid
Brand name
ATC Code
A06AB58
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Sodium picosulphate + magnesiumoxide + citric acid

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

All active ingredients act locally in the colon and are not absorbed in detectable amounts.

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Laxative as preparation for surgery, X-ray or endoscopic examination of the colon
  • Oral
    • 1 year up to 2 years
      • 2.5 mg/dose 1st dose: 10-18 hours prior to procedure
        2nd dose: 4-6 hours prior to procedure.
    • 2 years up to 4 years
      • 5 mg/dose 1st dose: 10-18 hours prior to procedure
        2nd dose: 4-6 hours prior to procedure.
    • 4 years up to 9 years

      • 10 mg/dose 10-18 hours prior to procedure and 5 mg/dose : 4-6 hours prior to procedure

    • 9 years up to 18 years
      • 10 mg/dose 1st dose: 10-18 hours prior to procedure
        2nd dose: 4-6 hours prior to procedure.

Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

DRUGS FOR CONSTIPATION

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Softeners, emollients
A06AA01
Contact laxatives
A06AB02
A06AB08
A06AB06
A06AB06
Bulk-forming laxatives
A06AC01
Osmotically acting laxatives
A06AD12
A06AD11
A06AD65
A06AD65
A06AD15
A06AD65
Enemas
A06AG
A06AG10
A06AG10
A06AG04
A06AG11
A06AG01
Other drugs for constipation
A06AX01
A06AX02

References

  1. Pinfield A. et al, Randomised trial of two pharmacological methods of bowel preparation for day case colonoscopy., Arch Dis Child, 1999, 80(2), 181-3
  2. Ferring BV, SPC Picoprep (RVG 106616) 17-06-2016, www.cbg-meb.nl
  3. MMI, Gelbe Liste I Online Laxoberal® Abführ-Tabletten, 5 mg Tabletten, 06/2018
  4. Ferring, SmPC Picoprep 10mg Pulver zur Herstllung einer Lösung zum Einnehmen (79572.00.00), 06/2016
  5. Sanofi, SmPC Laxoberal 2,5mg Weichkapseln (6926.00.04), 03/2007
  6. Sanofi, SmPC Laxoberal 7,5mg/ml Tropfen zum Einnehmen_Laxoberal 5mg Tabletten (6926.00.01_6926.00.00), 07/2017
  7. Sanofi, SmPC Dulcolax NP Kinder 7,5mg/ml Tropfen zum Einnehmen (22254.00.00), 06/2017
  8. MEDA, SmPC Agiolax Pico 5mg Abführ-Pastillen (6520998.00.00), 04/2015
  9. Krewel Meuselbach, SmPC Regulax Picosulfat 10mg Würfel (6751605.00.01), 08/2013
  10. Krewel Meuselbach, SmPC Regulax 7,23mg/ml Tropfen (6751605.00.00), 03/2013
  11. DAZ.online., Individuell für Kinder: Einige Besonderheiten der paediatrischen Rezeptur. , 05/2018
  12. Breitkreutz J BJ., Paediatric and geriatric drug delivery. Expert opinion on drug delivery, 2007, 4, 37-45
  13. DAZ.online., Individuell für Kinder: Einige Besonderheiten der paediatrischen Rezeptur., 05/2018

Changes

Therapeutic Drug Monitoring


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