Trospium

Generic name
Trospium
Brand name
ATC Code
G04BD09
Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

Trospiumchloride is absorbed primarily in the upper gastrointestinal tract and is barely absorbed in rectal use. [Schröder 2004]

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Urinary incontinence, overactive bladder syndrome, neurogenic bladder
  • Oral
    • 12 years up to 18 years
      • 30 - 45 mg/day in 2 - 3 doses.

      • Dosing according to clinical effects and side effects.

  • Rectal
    • 1 month up to 18 years

      • Systemic absorbtion after rectal admiistration is very limited.Therefore rectal use of Trospium is not recommended.

Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

Dry mouth, reddening of the skin, and palpitations, nausea occurred in a study in children aged 3-14 years [Lopez Pereira 1978]. Headache, dizziness, abdominal cramps and dry mouth were reported in a study in children aged 5-13 years [Schröder 2004].

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

UROLOGICALS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Acidifiers
G04BA01
Drugs for urinary frequency and incontinence
G04BD04
G04BD04
G04BD06
G04BD08
G04BD07
Drugs used in erectile dysfunction
G04BE03
G04BE08
Other urologicals
G04BX16
OTHER UROLOGICALS
G04BX16

References

  1. Kiesswetter, H., Conservative therapy in hyperactive detrusor muscle in women and special aspects in children, Krankenpfl J, 1991, 29(6), 271-3
  2. Dr. R. Pfleger, Chemische Fabrik GmbH, SmPC Spasmex® 5 mg Tabletten, 03/2021
  3. Dr. R. Pfleger, Chemische Fabrik GmbH, SmPC Spasmex® 15 mg Tabletten, 03/2021
  4. Schröder, S. et al., Absorption pattern of trospium chloride along the human gastrointestinal tract assessed using local enteral administration, Int J Clin Pharmacol Ther, 2004, 42(10), 543-9
  5. Dr. R. Pfleger, Chemische Fabrik GmbH, SmPC Spasmex® 20 mg Tabletten, 03/2021
  6. Dr. R. Pfleger, Chemische Fabrik GmbH, SmPC Spasmex® 45 mg Tabletten, 03/2021
  7. Wiedemann A., et al., Therapie der kindlichen Harninkontinenz mit Trospiumchlorid, Der Urologe, 1998, 38, 531-4
  8. Lopez Pereira, P. et al., Trospium chloride for the treatment of detrusor instability in children, J Urol, 2003, 170(5), 1978-81

Changes

Therapeutic Drug Monitoring


Overdose