- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
Trospiumchloride is absorbed primarily in the upper gastrointestinal tract and is barely absorbed in rectal use. [Schröder 2004]
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
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Available formulations
No information is present at this moment.
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Dosages
| Urinary incontinence, overactive bladder syndrome, neurogenic bladder |
|---|
|
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Renal impaiment in children > 3 months
No information available on dose adjustment in renal impairment.
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects in children
Dry mouth, reddening of the skin, and palpitations, nausea occurred in a study in children aged 3-14 years [Lopez Pereira 1978]. Headache, dizziness, abdominal cramps and dry mouth were reported in a study in children aged 5-13 years [Schröder 2004].
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions
No information available on specific warnings and precautions in children.
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| Acidifiers | ||
|---|---|---|
| G04BA01 | ||
| Drugs for urinary frequency and incontinence | ||
|---|---|---|
| G04BD04 | ||
| G04BD04 | ||
| G04BD06 | ||
| G04BD08 | ||
| G04BD07 | ||
| Drugs used in erectile dysfunction | ||
|---|---|---|
| G04BE03 | ||
| G04BE08 | ||
| Other urologicals | ||
|---|---|---|
| G04BX16 | ||
| OTHER UROLOGICALS | ||
|---|---|---|
| G04BX16 | ||
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References
- Kiesswetter, H., Conservative therapy in hyperactive detrusor muscle in women and special aspects in children, Krankenpfl J, 1991, 29(6), 271-3
- Dr. R. Pfleger, Chemische Fabrik GmbH, SmPC Spasmex® 5 mg Tabletten, 03/2021
- Dr. R. Pfleger, Chemische Fabrik GmbH, SmPC Spasmex® 15 mg Tabletten, 03/2021
- Schröder, S. et al., Absorption pattern of trospium chloride along the human gastrointestinal tract assessed using local enteral administration, Int J Clin Pharmacol Ther, 2004, 42(10), 543-9
- Dr. R. Pfleger, Chemische Fabrik GmbH, SmPC Spasmex® 20 mg Tabletten, 03/2021
- Dr. R. Pfleger, Chemische Fabrik GmbH, SmPC Spasmex® 45 mg Tabletten, 03/2021
- Wiedemann A., et al., Therapie der kindlichen Harninkontinenz mit Trospiumchlorid, Der Urologe, 1998, 38, 531-4
- Lopez Pereira, P. et al., Trospium chloride for the treatment of detrusor instability in children, J Urol, 2003, 170(5), 1978-81
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Changes
Changes
