Pharmacokinetics in children

The inhaled concentration required to achieve clinical anaesthesia depends on the patient's age. The minimum alveolar concentration (MAC) of isoflurane in oxygen increases from an average of 1.6% in neonates to 1.87% in infants of 6 months, and then gradually down with age to 1.28% in young adults and 1.05% in elderly patients.

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

• NERVOUS SYSTEM
• ANESTHETICS

ANESTHETICS, GENERAL

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

References

1. Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor kinderen, 2007
2. Minrad EU, SPC Isofluraan Minrad (RVG 22940), www.cbg-meb.nl, Geraadpleegd 4 juni 2010, http://db.cbg-meb.nl/IB-teksten/h22940.pdf

Changes

Therapeutic Drug Monitoring

Overdose