- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
The inhaled concentration required to achieve clinical anaesthesia depends on the patient's age. The minimum alveolar concentration (MAC) of isoflurane in oxygen increases from an average of 1.6% in neonates to 1.87% in infants of 6 months, and then gradually down with age to 1.28% in young adults and 1.05% in elderly patients.
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
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Available formulations
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Dosages
| Inhalation anaesthesia |
|---|
|
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Renal impaiment in children > 3 months
No information available on dose adjustment in renal impairment.
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions
No information available on specific warnings and precautions in children.
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| Halogenated hydrocarbons | ||
|---|---|---|
| N01AB08 | ||
| Other general anesthetics | ||
|---|---|---|
| N01AX14 | ||
| N01AX10 | ||
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References
- Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor kinderen, 2007
- Minrad EU, SPC Isofluraan Minrad (RVG 22940), www.cbg-meb.nl, Geraadpleegd 4 juni 2010, http://db.cbg-meb.nl/IB-teksten/h22940.pdf
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Changes
Changes
