Tobramycin ocular application

Generic name
Tobramycin ocular application
Brand name
ATC Code
S01AA12
Compare …

Tobramycin ocular application

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Severe bacterial eye infections
  • Ocular
    • 0 years up to 18 years
      [1] [2] [3] [5] [6]
      • Both eyes: 1 drop(s)/dose 2-6x daily. Alternative: 1 cm ointment.
      • Duration of treatment:

        14 days

      • Treatment by or after consulting a paediatric specialist (paediatric ophthalmologist) who has experience of using tobramycin eye drops.

Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

Irritation, itching, oedema of the eyelids

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

ANTIINFECTIVES

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Antibiotics
S01AA26
S01AA11
S01AA24
Antivirals
S01AD03
ANTIBIOTICS
S01AA26
S01AA11
S01AA24
ANTIVIRALS
S01AD03
Fluoroquinolones
S01AE07
S01AE01

References

  1. Bremond-Gignac D, et al, Efficacy and safety of azithromycin 1.5% eye drops for purulent bacterial conjunctivitis in pediatric patients, Pediatr Infect Dis J., 2010, Mar;29(3):, 222-6
  2. Protzko E et al, Phase 3 safety comparisons for 1.0% azithromycin in polymeric mucoadhesive eye drops versus 0.3% tobramycin eye drops for bacterial conjunctivitis., Invest Ophthalmol Vis Sci, 2007 , Aug;48(8), 3425-9
  3. Jackson WB et al, Treatment of acute bacterial conjunctivitis: 1% fusidic acid viscous drops vs.0.3% tobramycin drops, Can J Ophthalmol. , 2002, Jun;37(4), 228-37
  4. Sheikh A et al, Antibiotics for acute bacterial conjunctivitis, Cochrane Database Syst Rev., 2000, 2006, CD001211
  5. Gallenga PE et al, Topical lomefloxacin 0.3% twice daily versus tobramycin 0.3% in acute bacterial conjunctivitis: A multicenter double-blind phase III study, Ophthalmologica, 1999, 213(4), 250-7
  6. Gross RD, et al, A comparison of ciprofloxacin and tobramycin in bacterial conjunctivitis in children. , Clin Pediatr (Phila). , 1997, Aug;36(8):, 435-44

Changes

Therapeutic Drug Monitoring


Overdose