Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Tobramycin ocular application

Generic name
Tobramycin ocular application
Brand name
ATC Code
S01AA12

Pharmacokinetics in children

No information

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

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Available formulations

No information is present at this moment.

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Dosages

Severe bacterial eye infections
  • Ocular
    • 0 years up to 18 years
      [1] [2] [3] [5] [6]
      • Both eyes: 1 drop(s)/dose 2-6x daily. Alternative: 1 cm ointment.
      • Duration of treatment:

        14 days

      • Treatment by or after consulting a paediatric specialist (paediatric ophthalmologist) who has experience of using tobramycin eye drops.

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Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

Irritation, itching, oedema of the eyelids

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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References

  1. Bremond-Gignac D, et al, Efficacy and safety of azithromycin 1.5% eye drops for purulent bacterial conjunctivitis in pediatric patients, Pediatr Infect Dis J., 2010, Mar;29(3):, 222-6
  2. Protzko E et al, Phase 3 safety comparisons for 1.0% azithromycin in polymeric mucoadhesive eye drops versus 0.3% tobramycin eye drops for bacterial conjunctivitis., Invest Ophthalmol Vis Sci, 2007 , Aug;48(8), 3425-9
  3. Jackson WB et al, Treatment of acute bacterial conjunctivitis: 1% fusidic acid viscous drops vs.0.3% tobramycin drops, Can J Ophthalmol. , 2002, Jun;37(4), 228-37
  4. Sheikh A et al, Antibiotics for acute bacterial conjunctivitis, Cochrane Database Syst Rev., 2000, 2006, CD001211
  5. Gallenga PE et al, Topical lomefloxacin 0.3% twice daily versus tobramycin 0.3% in acute bacterial conjunctivitis: A multicenter double-blind phase III study, Ophthalmologica, 1999, 213(4), 250-7
  6. Gross RD, et al, A comparison of ciprofloxacin and tobramycin in bacterial conjunctivitis in children. , Clin Pediatr (Phila). , 1997, Aug;36(8):, 435-44

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Changes

Changes