Riboflavin

Generic name
Riboflavin
Brand name
ATC Code
A11HA04
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Riboflavin

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

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Pyruvate dehydrogenase complex 1
  • Oral
    • 0 years up to 18 years
      [1]
      • 3 - 20 mg/kg/day in 3 - 4 doses.

      • Treatment by or after consultations with a paediatric specialist (metabolic disorders) who has experience using riboflavin for this indication.

        ...read more
Acute treatment of glutaric aciduria, type II
  • Intravenous
    • 0 years up to 18 years
      [1]
      • 150 mg/day in 3 doses.

      • Treatment by or after consultations with a paediatric specialist (metabolic disorders) who has experience using riboflavin for this indication.

        ...read more
Glutaric aciduria, type I
  • Oral
    • 0 years up to 18 years
      [1]
      • 100 mg/day in 2 doses.

      • Treatment by or after consultations with a paediatric specialist (metabolic disorders) who has experience using riboflavin for this indication

        ...read more
5,10-methylenetetrahydrofolate reductase (MTHFR)
  • Oral
    • 1 year up to 2 years
      [1]
      • 5 mg/day in 2 - 3 doses.

      • Treatment by or after consultations with a paediatric specialist (metabolic disorders) who has experience using riboflavin for this indication

        ...read more
    • 2 years up to 18 years
      [1]
      • 5 - 10 mg/day in 2 - 3 doses.

      • Treatment by or after consultations with a paediatric specialist (metabolic disorders) who has experience using riboflavin for this indication

        ...read more
ETF, responsive to vitamin B2
  • Oral
    • 0 years up to 18 years
      [1]
      • 100 - 300 mg/day in 3 doses.

      • Treatment by or after consultations with a paediatric specialist (metabolic disorders) who has experience using riboflavin for this indication.

        ...read more

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

OTHER PLAIN VITAMIN PREPARATIONS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Other plain vitamin preparations
A11HA02

Reference

  1. Blau, Hoffmann, Leonard and Clarke, Physicians guide to the treatment and follow-up of metabolic diseases, Springer, 2006

Changes

Therapeutic Drug Monitoring


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