Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Riboflavin

Generic name
Riboflavin
Brand name
ATC Code
A11HA04

Pharmacokinetics in children

No information

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

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Available formulations

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Dosages

Pyruvate dehydrogenase complex 1
  • Oral
    • 0 years up to 18 years
      [1]
      • 3 - 20 mg/kg/day in 3 - 4 doses.
      • Treatment by or after consultations with a paediatric specialist (metabolic disorders) who has experience using riboflavin for this indication.

        ...read more
Acute treatment of glutaric aciduria, type II
  • Intravenous
    • 0 years up to 18 years
      [1]
      • 150 mg/day in 3 doses.
      • Treatment by or after consultations with a paediatric specialist (metabolic disorders) who has experience using riboflavin for this indication.

        ...read more
Glutaric aciduria, type I
  • Oral
    • 0 years up to 18 years
      [1]
      • 100 mg/day in 2 doses.
      • Treatment by or after consultations with a paediatric specialist (metabolic disorders) who has experience using riboflavin for this indication

        ...read more
5,10-methylenetetrahydrofolate reductase (MTHFR)
  • Oral
    • 1 year up to 2 years
      [1]
      • 5 mg/day in 2 - 3 doses.
      • Treatment by or after consultations with a paediatric specialist (metabolic disorders) who has experience using riboflavin for this indication

        ...read more
    • 2 years up to 18 years
      [1]
      • 5 - 10 mg/day in 2 - 3 doses.
      • Treatment by or after consultations with a paediatric specialist (metabolic disorders) who has experience using riboflavin for this indication

        ...read more
ETF, responsive to vitamin B2
  • Oral
    • 0 years up to 18 years
      [1]
      • 100 - 300 mg/day in 3 doses.
      • Treatment by or after consultations with a paediatric specialist (metabolic disorders) who has experience using riboflavin for this indication.

        ...read more

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Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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Other plain vitamin preparations
A11HA02

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Reference

  1. Blau, Hoffmann, Leonard and Clarke, Physicians guide to the treatment and follow-up of metabolic diseases, Springer, 2006

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Changes

Changes