Vecuronium

Generic name
Vecuronium
Brand name
ATC Code
M03AC03
Compare …

Vecuronium

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

Vd:0,29- 0,43 l/kg (infants and adults) en 0,13-0,32 l/kg (children)
Cl: 2,8-9,0 ml/kg/min (neonates, infants, children and adults)

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Weakening of the skeletal muscles
  • Intravenous
    • Premature infants Gestational age < 37 weeks
      [1] [2]
      • Initial dose: In intubation: 0.1 mg/kg/dose, once only.
      • Maintenance dose: 0.025 - 0.05 mg/kg/hour, continuous infusion.
    • Full-term neonates and infants 0 months up to 5 months
      [2]
      • Initial dose: Vecuroniumbromid: 0.01 - 0.02 mg/kg/dose, once only.
      • Maintenance dose: Gradually increase test dose until 90-95% suppression of twitch response is achieved: Vecuroniumbromid:
         0.02 - 0.1         mg/kg/dose, as required additional doses based on twitch reponse. Max: 0.1 mg/kg/dose.
    • 5 months up to 18 years
      [2]
      • Initial dose: In intubation: Vecuroniumbromid: 0.08 - 0.1 mg/kg/dose, once only.
      • Maintenance dose: Vecuroniumbromid: 0.05 - 0.1 mg/kg/hour, continuous infusion.  .
        • In infants 5 months - 2 y.ears no high intubation doses are usually necessary (due to a faster onset of efficacy in this age group).
        • In children 2 years - 11 years, shorter intervals between maintenance doses are usually necessary (due to the shorter duration of efficacy in this age group).
        • ALTERNATIVE: Vecuroniumbromid: 0.02-0.03 mg/kg/dose

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

MUSCLE RELAXANTS, PERIPHERALLY ACTING AGENTS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Choline derivatives
M03AB01
Other quaternary ammonium compounds
M03AC04

References

  1. Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
  2. Sun Pharmaceutical Industries Europe B.V., SmPC Vecuronium (RVG 118278) 09-01-2021, www.geneesmiddeleninformatiebank.nl

Changes

Therapeutic Drug Monitoring


Overdose