Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Vecuronium

Generic name
Vecuronium
Brand name
ATC Code
M03AC03

Pharmacokinetics in children

Vd:0,29- 0,43 l/kg (infants and adults) en 0,13-0,32 l/kg (children)
Cl: 2,8-9,0 ml/kg/min (neonates, infants, children and adults)

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

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Available formulations

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Dosages

Weakening of the skeletal muscles
  • Intravenous
    • Premature infants Gestational age < 37 weeks
      [1] [2]
      • Initial dose: In intubation: 0.1 mg/kg/dose, once only.
      • Maintenance dose: 0.025 - 0.05 mg/kg/hour, continuous infusion.
    • Full-term neonates and infants 0 months up to 5 months
      [2]
      • Initial dose: Vecuroniumbromid: 0.01 - 0.02 mg/kg/dose, once only.
      • Maintenance dose: Gradually increase test dose until 90-95% suppression of twitch response is achieved: Vecuroniumbromid:
         0.02 - 0.1         mg/kg/dose, as required additional doses based on twitch reponse. Max: 0.1 mg/kg/dose.
    • 5 months up to 18 years
      [2]
      • Initial dose: In intubation: Vecuroniumbromid: 0.08 - 0.1 mg/kg/dose, once only.
      • Maintenance dose: Vecuroniumbromid: 0.05 - 0.1 mg/kg/hour, continuous infusion.  .
        • In infants 5 months - 2 y.ears no high intubation doses are usually necessary (due to a faster onset of efficacy in this age group).
        • In children 2 years - 11 years, shorter intervals between maintenance doses are usually necessary (due to the shorter duration of efficacy in this age group).
        • ALTERNATIVE: Vecuroniumbromid: 0.02-0.03 mg/kg/dose

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Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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Choline derivatives
M03AB01
Other quaternary ammonium compounds
M03AC04

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References

  1. Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
  2. Sun Pharmaceutical Industries Europe B.V., SmPC Vecuronium (RVG 118278) 09-01-2021, www.geneesmiddeleninformatiebank.nl

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Changes

Changes