Ethosuximide

Generic name
Ethosuximide
Brand name
ATC Code
N03AD01
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Ethosuximide

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

Half-life in children: approximately 30 hours

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Epilepsy, absences
  • Oral
    • 1 month up to 3 years
      [3]
      • Initial dose: 10 mg/kg/day in 1 - 2 doses.
      • Maintenance dose: 20 - 40 mg/kg/day in 1 - 2 doses. Max: 1.000 mg/day.
    • 3 years up to 6 years
      [3]
      • Initial dose: 250 mg/day in 2 doses.
      • Maintenance dose: Increase the daily dose if necessary every 4-7 days by 125 mg to 375 - 1.000 mg/day in 2 doses.
    • ≥ 6 years
      [3]
      • Initial dose: 500 mg/day in 2 doses.
      • Maintenance dose: Increase the daily dose if necessary every 4-7 days by 125 mg to 625 - 1.500 mg/day in 2 doses. Max: 2.000 mg/day.

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

Gastrointestinal complaints, fatigue, sometimes behavioural abnormalities, psychotic reactions [Rademaker 2007]

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

ANTIEPILEPTICS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Barbiturates and derivatives
N03AA02
Hydantoin derivatives
N03AB02
Carboxamide derivatives
N03AF01
Fatty acid derivatives
N03AG01
Other antiepileptics
N03AX09
N03AX14

References

  1. Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
  2. NVN Werkgroep Richtlijnen Epilepsie, Epilepsie. Richtlijnen voor diagnostiek en behandeling, Herziene, tweede versie, januari 2006
  3. Apotex Europe BV, SmPC Ethymal (RVG 02984) 27-03-2018, www.geneesmiddeleninformatiebank.nl

Changes

Therapeutic Drug Monitoring


Overdose