- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
Half-life in children: approximately 30 hours
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
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Available formulations
No information is present at this moment.
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Dosages
| Epilepsy, absences |
|---|
|
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Renal impaiment in children > 3 months
GFR ≥10 ml/min/1.73m2: Dose adjustment not required.
GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects in children
Gastrointestinal complaints, fatigue, sometimes behavioural abnormalities, psychotic reactions [Rademaker 2007]
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions
No information available on specific warnings and precautions in children.
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| Barbiturates and derivatives | ||
|---|---|---|
| N03AA02 | ||
| Hydantoin derivatives | ||
|---|---|---|
| N03AB02 | ||
| Carboxamide derivatives | ||
|---|---|---|
| N03AF01 | ||
| Fatty acid derivatives | ||
|---|---|---|
| N03AG01 | ||
| Other antiepileptics | ||
|---|---|---|
| N03AX09 | ||
| N03AX14 | ||
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References
- Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
- NVN Werkgroep Richtlijnen Epilepsie, Epilepsie. Richtlijnen voor diagnostiek en behandeling, Herziene, tweede versie, januari 2006
- Apotex Europe BV, SmPC Ethymal (RVG 02984) 27-03-2018, www.geneesmiddeleninformatiebank.nl
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Changes
Changes
