Pharmacokinetics in children

No information

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Allergic rhinitis and chronic urticaria

Oral 15 up to 30 kg [2] [3] [4] 5 mg/day in 1 dose In chronic urticaria, raising the dose can be considered up to a maximum of 4 times the daily dose. TAKE CARE when using the liquid formulation in high dosages for the indication urticaria. The liquid formulation contains propylene glycol.  ≥ 30 kg [2] [3] [4] 10 mg/day in 1 dose In chronic urticaria, raising the dose can be considered up to a maximum of 4 times the daily dose.

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

In children between the ages of 2 and 12, common side effects were headache (2.7%), nervousness (2.3%), and tiredness (1%).

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Use caution in patients with severe hepatic impairment: dose adjustment:

<30 kg: 5 mg / dose every other day
>30 kg: 10mg / dose every other day (SmPC Clarityn)

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

• RESPIRATORY SYSTEM
• ANTIHISTAMINES FOR SYSTEMIC USE

ANTIHISTAMINES FOR SYSTEMIC USE

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Piperazine derivatives
	Cetirizine Related Medicines Menu">	R06AE07
	Cyclizine Related Medicines Menu">	R06AE03

Other antihistamines for systemic use
	Fexofenadine Related Medicines Menu">	R06AX26

References

1. Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
2. Schering Plought Nederland BV, SPC Claritine (RVG 13492), www.cbg-meb.nl, Geraadpleegd 4 juni 2010, http://db.cbg-meb.nl/IB-teksten/h13492.pdf
3. Nederlandse Vereniging voor Dermatologie en Venereologie, Richtlijn Chronische spontane urticaria., www.ndvd.nl, 03-12-2015
4. Zuberbier T, et al, , The EAACI/GA(2) LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update., Allergy, 2014 , Jul;69(7), 868-87

Changes

Therapeutic Drug Monitoring

Overdose