Paromomycin

Generic name
Paromomycin
Brand name
ATC Code
A07AA06
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Paromomycin

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

Paromomycin is absorbed to a small extent.

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Amoebiasis, Dientamoeba fragilis
  • Oral
    • 1 month up to 18 years
      [1] [2] [3] [5] [6]
      • 25 - 35 mg/kg/day in 3 doses. Max: 1.500 mg/day.
      • Duration of treatment:

        7 days

      • Only very few studies have been carried out into the use of paromomycin in children.

Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

Tetany has been reported after intramuscular administration [Thakur 2008].
Based on the available data, the same side effect profile is expected in children and adolescents as in adults. [SmPC Humatin]

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Caution is needed in cases of renal function disorders; the possibility of accumulation cannot be excluded.

 

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

INTESTINAL ANTIINFECTIVES

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Antibiotics
A07AA02
A07AA09
ANTIBIOTICS
A07AA02
A07AA09

References

  1. Hartwig NC et al, Vademecum Pediatrische Antimicrobiele Therapie, 2005
  2. Frisari L, et al, An open, controlled study of two non-absorbable antibiotics for the oral treatment of paediatric infectious diarrhoea., Curr Med Res Opin, 1997, 14(1), 39-45
  3. Vandenberg O, et al, Treatment of Dientamoeba fragilis infection with paromomycin. , Pediatr Infect Dis J. , 2007 , Jan;26(1), 88-90
  4. Thakur CP. , Tetany in kala azar patients treated with paromomycine, Indian J Med Res, 2008, May;127(5), 489-93
  5. Pfizer, SmPC Humatin® Kapseln, 250 mg Hartkapseln (6419615.00.00), 11/2018
  6. Pfizer, SmPC Humatin® Pulvis, 1.000 mg Pulver zur Herstellung einer Lösung zum Einnehmen (40332.00.00), 11/2018

Changes

Therapeutic Drug Monitoring


Overdose