Rabiësvaccin

Generic name
Rabiësvaccin
Brand name
ATC Code
J07BG01
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Rabiësvaccin

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information is present at this moment.

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Post-exposure prophylaxis rabies
  • Intramuscular
    • 0 years up to 18 years

      • IMMUNO COMPETENT CHILDREN
        Unvaccinated:
        Essen regimen: 1 dose on day 0, day 3, day 7, day 14 and 28 (5 injections)
        Alternative: Zagreb regimen: two doses (2 injections) in two different body parts on day 0, followed by 1 dose on day 7 and day 21 (4 injections in total).
        Combined use with antirabies immunoglobulines only indicated in type III exposures
        Vaccinated:
        1 dose on day 0 and day 3 (total of 2 injections) 

        IMMUNOCOMPROMISED CHILDREN

        • Unvaccinated: 1 dose on day 0, day 3, day 7, day 14 and day 28 (total of 5 injections), combined with antirabies immunoglobulines  on day 0 (or at least within 7 days of exposure)
        • Vaccinated:
          1 dose on day 0 and day 3 (total of 2 injections), combined with antirabies immunoglobulines  on day 0 (or at least within 7 days of exposure)



         

      • Administer into the deltoid muscle, or in young children into the anterolateral part of the thigh. Do not inject into the gluteal muscle.

    • 0 years up to 18 years
      [1]

      • Unvaccinated:
        1 ml/dose on day 0, day 3, day 7, day 14 and day 28 (5 injections)
        Alternative: two injections of 1 ml/dose in two different body parts on day 0, followed by 1 injection (1 ml/dose) on day 7 and day 21 (4 injections in total).

        Vaccinated:
        <5 years ago: 1 ml/dose on day 0 and day 3 (2 injections)
        >5 years ago or incomplete: 1 ml/dose on day 0, day 3, day 7, day 14 and day 28 (5 injections) with 20 IU/kg human anti-rabies immunoglobulin as needed
         
Pre-exposure prophylaxis rabies
  • Intramuscular
    • 0 years up to 1 year

      • 1 dose on day 0, day 7 and day 21 (or 28)

    • 1 year up to 18 years

      • 1 dose on day 0 and day 7

Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

In small children, drowsiness, irritability and inconsolable crying.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

When the primary vaccination series of this vaccine is administered to very premature infants (born at 28 weeks gestation or earlier), the potential risk of apnea and the need for airway monitoring for 48-72 hours should be considered, especially in children with a history of respiratory immaturity.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

VIRAL VACCINES

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Encephalitis vaccines
J07BA02
J07BA01
Influenza vaccines
J07BB02
J07BB02
Hepatitis vaccines
J07BC20
J07BC02
J07BC01
Measles vaccines
J07BD52
Poliomyelitis vaccines
J07BF03
Rota virus diarrhea vaccines
J07BH01
Varicella zoster vaccines
J07BK01
Yellow fever vaccines
J07BL01
Papillomavirus vaccines
J07BM03
J07BM02
Other viral vaccines
J07BX04
Covid-19 vaccines
J07BN01

References

  1. Sanofi Pasteur Europe, SmPC Geïnactiveerd Rabiësvaccin Mérieux HDCV (RVG 18718) 31-3-2020, www.geneesmiddeleninformatiebank.nl
  2. Sanofi Winthrop Industrie, SmPC Verorab (RVG130934) 18-12-2024, www.geneesmiddelinformatiebank.nl
  3. Bavarian Nordic A/S, SmPC Rabipur (RVG 117796) 11-10-2024, www.geneesmiddelinformatiebank.nl
  4. World Health Organisation, Rabies vaccines: WHO position paper, https://iris.who.int/bitstream/handle/10665/272371/WER9316.pdf?ua=1, April 2018

Changes

Therapeutic Drug Monitoring


Overdose