Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Diltiazem

Generic name
Diltiazem
Brand name
ATC Code
C05AE03

Pharmacokinetics in children

Localized resorption can occur.

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

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Available formulations

No information is present at this moment.

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Dosages

Anal fissure
  • Rectal
    • 1 month up to 18 years
      • 2%: Apply twice daily to the fissure and the skin around the anus

      • Duration of treatment:

        Do this until the fissure is visually healed or until there are no more complaints, max. 12 weeks.

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Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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References

  1. Cevik M, et al, A prospective, randomized, double-blind study comparing the efficacy of diltiazem, glyceryl trinitrate, and lidocaine for the treatment of anal fissure in children,, Pediatr Surg Int, 2012, 28, 411-6
  2. Bouma M. et al, NHG-Standaard Rectaal bloedverlies, Huisarts Wet, 2009, 52(1), 23-38

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Changes

Changes