Note:
the dose and dosing frequency of cytostatic agents depend on the condition and are very much subject to new insights. Cytostatic drugs are mostly used in oncology and haematology in combinations. For this reason, please refer to the detailed treatment protocols.

The following indicative dosages have been stated by the manufacturer:

Autologous haematopoietic stem cell transplants
For solid tumours:
6-14 mg/kg/day IV in a single dose (equivalent to 150-350 mg/m²/day) for 2-3 successive days before HPCT. The maximum cumulative dose is 42 mg/kg, equivalent to 1050 mg/m².
For CNS tumours:
10-14 mg/kg/day in a single IV dose (equivalent to 250-350 mg/m²/day) for 3 successive days before HPCT. Max cumulative dose: 42 mg/kg, equivalent to 1050 mg/m².

Allogeneic haematopoietic stem cell transplants
Haematological diseases:
5-10 mg/kg/day in 1-2 IV doses (equivalent to 125-250 mg/m²/day) for 1-3 successive days before HPCT. Max cumulative dose: 15 mg/kg, equivalent to 375 mg/m².
Leukaemia: 10 mg/kg/day in two IV doses (equivalent to 250 mg/m²/day) before HPCT, maximum cumulative dose 10 mg/kg (equivalent to 250 mg/m²).
Thalassaemia: 8-10 mg/kg/day in two IV doses (equivalent to 200-250 mg/m²/day) before HPCT, maximum cumulative dose 10 mg/kg (equivalent to 250 mg/m²).
Refractory cytopenia: 5 mg/kg/day in a single IV dose (equivalent to 125 mg/m²/day) for 3 successive days before HPCT; maximum cumulative dose 15 mg/kg (equivalent to 375 mg/m²).
Genetic diseases: 5 mg/kg/day in a single IV dose (equivalent to 125 mg/m²/day) for 2 successive days before HPCT; maximum cumulative dose 10 mg/kg (equivalent to 250 mg/m²).
Sickle cell anaemia: 10 mg/kg/day in two IV doses (equivalent to 250 mg/m²/day) before HPCT, maximum cumulative dose 10 mg/kg (equivalent to 250 mg/m²).