Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Proguanil

Generic name
Proguanil
Brand name
ATC Code
P01BB01

Pharmacokinetics in children

No information is present at this moment.

A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.

Available formulations

No information is present at this moment.

A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.

Dosages

Prophylaxis for malaria
  • Oral
    • < 1 year
      • 25 mg/day in 1 dose
    • 1 year up to 5 years
      • 50 mg/day in 1 dose
    • 5 years up to 9 years
      • 100 mg/day in 1 dose
    • 9 years up to 15 years
      • 150 mg/day in 1 dose
    • ≥ 15 years
      • 200 mg/day in 1 dose

A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.

Renal impaiment in children > 3 months

Adjustment in renal impairment as specified:

GFR 50-80 ml/min/1.73 m2
100 percentage of single dose and dosing interval : 24 uur
GFR 30-50 ml/min/1.73 m2
50 percentage of single dose and dosing interval : 24 uur
GFR 10-30 ml/min/1.73 m2
Do not administer
GFR < 10 ml/min/1.73 m2
Do not administer
Clinical consequences

The clearance of proguanil is less when the renal function is reduced. The risk of side effects is elevated as a result.

Symptoms of overdose include haematuria, nausea, vomiting and pain in the kidney region. Aplastic and megaloblastic anaemia can occur.

A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.

Aminoquinolines
P01BA01
P01BA02
Biguanides
P01BB51
Methanolquinolines
P01BC02
P01BC01
Diaminopyrimidines
P01BD01
Artemisinin and derivatives, plain
P01BE03
Artemisinin and derivatives, combinations
P01BF01
P01BF05

A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.

References

  1. LCR, Malariaprofylaxebulletin 2015
  2. Alliance Pharmaceuticals Limited, SmPC Paludrine (RVG 00550) 09-12-2013, www.geneesmiddeleninformatiebank.nl

A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.

Changes

Changes