- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
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Available formulations
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Dosages
| Prophylaxis for malaria |
|---|
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Renal impaiment in children > 3 months
Adjustment in renal impairment as specified:
GFR 50-80 ml/min/1.73 m2
100 percentage of single dose and dosing interval : 24 uurGFR 30-50 ml/min/1.73 m2
50 percentage of single dose and dosing interval : 24 uurGFR 10-30 ml/min/1.73 m2
Do not administerGFR < 10 ml/min/1.73 m2
Do not administerClinical consequences
The clearance of proguanil is less when the renal function is reduced. The risk of side effects is elevated as a result.
Symptoms of overdose include haematuria, nausea, vomiting and pain in the kidney region. Aplastic and megaloblastic anaemia can occur.
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions
No information available on specific warnings and precautions in children.
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| Aminoquinolines | ||
|---|---|---|
| P01BA01 | ||
| P01BA02 | ||
| Methanolquinolines | ||
|---|---|---|
| P01BC02 | ||
| P01BC01 | ||
| Diaminopyrimidines | ||
|---|---|---|
| P01BD01 | ||
| Artemisinin and derivatives, plain | ||
|---|---|---|
| P01BE03 | ||
| Artemisinin and derivatives, combinations | ||
|---|---|---|
| P01BF01 | ||
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References
- LCR, Malariaprofylaxebulletin 2015
- Alliance Pharmaceuticals Limited, SmPC Paludrine (RVG 00550) 09-12-2013, www.geneesmiddeleninformatiebank.nl
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Changes
Changes
