- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
The absorption of adapalene through the skin is low; in clinical studies, with an analytical sensitivity of 0.15 ng / ml, no measurable adapalene concentrations in plasma were found after chronic cutaneous administration on large area of acne skin.
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
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Available formulations
No information is present at this moment.
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Dosages
| Acne vulgaris |
|---|
|
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Renal impaiment in children > 3 months
GFR ≥10 ml/min/1.73m2: Dose adjustment not required.
GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects
No information is present at this moment.
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions
No information available on specific warnings and precautions in children.
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| Retinoids for topical use in acne | ||
|---|---|---|
| D10AD53 | ||
| D10AD01 | ||
| Peroxides | ||
|---|---|---|
| D10AE01 | ||
| Antiinfectives for treatment of acne | ||
|---|---|---|
| D10AF51 | ||
| D10AF01 | ||
| D10AF02 | ||
| D10AF51 | ||
| Other anti-acne preparations for topical use | ||
|---|---|---|
| D10AX03 | ||
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Reference
- Galderma Benelux B.V., SmPC Differin gel (RVG 32496) 19-09-2014, www.geneesmiddeleninformatiebank.nl
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Changes
Changes
