- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
Serum concentrations of ustekinumab in children with psoriasis (aged 6 to 17 years) and in children with Crohn's disease (weighing at least 40 kg) treated with the recommended dose based on body weight were generally comparable to those in adult patients.
Serum concentrations of ustekinumab in pediatric psoriasis patients aged 12 to 17 years (CADMUS) treated with half the recommended dose based on body weight were generally lower than those in adults.
Kinetic data in adults:
| Subcutaneous | Intravenuus | |
| Tmax | ca. 8½ day | 1 hour |
| Vd | 0,06–0,08 l/kg, greater for a body weight > 100 kg | 57-83 ml/kg |
| T1/2 | circa 3 weken (15–32 days), shorter for a body weight > 100 kg | |
| Cl | 1,99 tot 2,34 ml/day/kg |
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
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Available formulations
No information is present at this moment.
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Dosages
| Moderate to severe plaque psoriasis, with insufficient response to or intolerance of other therapy |
|---|
|
| Crohn’s disease |
|---|
|
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Renal impaiment in children > 3 months
No information available on dose adjustment in renal impairment.
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects in children
The side effect profile in children is generally similar to that in adults.
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions
No information available on specific warnings and precautions in children.
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| Selective immunosuppressants | ||
|---|---|---|
| L04AA24 | ||
| L04AA32 | ||
| L04AA13 | ||
| L04AA02 | ||
| L04AA06 | ||
| L04AA31 | ||
| L04AA04 | ||
| L04AA44 | ||
| Other immunosuppressants | ||
|---|---|---|
| L04AX01 | ||
| L04AX03 | ||
| Tumor necrosis factor alpha (TNF-alpha) inhibitors | ||
|---|---|---|
| L04AB04 | ||
| L04AB01 | ||
| L04AB06 | ||
| L04AB02 | ||
| Interleukin inhibitors | ||
|---|---|---|
| L04AC03 | ||
| L04AC02 | ||
| L04AC08 | ||
| L04AC13 | ||
| L04AC19 | ||
| L04AC10 | ||
| L04AC22 | ||
| L04AC07 | ||
| Calcineurin inhibitors | ||
|---|---|---|
| L04AD01 | ||
| L04AD02 | ||
| Sphingosine-1-phosphate (S1P) receptor modulators | ||
|---|---|---|
| L04AE01 | ||
| Janus-associated kinase (JAK) inhibitors | ||
|---|---|---|
| L04AF02 | ||
| L04AF02 | ||
| L04AF08 | ||
| L04AF01 | ||
| Monoclonal antibodies | ||
|---|---|---|
| L04AG04 | ||
| Mammalian target of rapamycin (mTOR) kinase inhibitors | ||
|---|---|---|
| L04AH02 | ||
| L04AH01 | ||
| Complement inhibitors | ||
|---|---|---|
| L04AJ01 | ||
| L04AJ02 | ||
| Dihydroorotate dehydrogenase (DHODH) inhibitors | ||
|---|---|---|
| L04AK02 | ||
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References
- Janssen-Cilag International NV, SmPC Stelara( EU/1/08/494/001) 18-11-2021, www.ema.europa.eu
- Janssen-Cilag International NV, SmPC Stelara( EU/1/08/494/001) Rev 51; 14-04-2025, www.ema.europa.eu
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Changes
Changes
