- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
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Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
There is no data on the pharmacokinetics in children and adolescents.
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
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Available formulations
No information is present at this moment.
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Dosages
| Heterozygous familial hypercholesterolaemia |
|---|
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Renal impaiment in children > 3 months
The dose does not need to be adjusted for moderate renal function disorders. If the patient has a severe renal insufficiency (creatinine clearance < 30 ml/min) caution is recommended for dosages above 10 mg/day.
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects in children
Patients 10-17 years treated with simvastatin had an adverse experience profile generally similar to that of patients treated with placebo. Doses greater than 40 mg have not been studied in this population. In this limited controlled study, there was no detectable effect on growth or sexual maturation in the adolescent boys or girls, or any effect on menstrual cycle length in girls. Long-term effects on physical, intellectual, and sexual maturation are unknown. (SmPC Zocor)
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions
No information available on specific warnings and precautions in children.
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| HMG CoA reductase inhibitors | ||
|---|---|---|
| C10AA05 | ||
| C10AA03 | ||
| C10AA07 | ||
| Bile acid sequestrants | ||
|---|---|---|
| C10AC01 | ||
| Other lipid modifying agents | ||
|---|---|---|
| C10AX09 | ||
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Reference
- Merck Sharp & Dohme BV, SPC Zocor (RVG 13193) 22-06-2015, www.geneesmiddeleninformatiebank.nl
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Changes
Changes
