Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Sodium picosulphate + magnesiumoxide + citric acid

Generic name
Sodium picosulphate + magnesiumoxide + citric acid
Brand name
ATC Code
A06AB58

Pharmacokinetics in children

All active ingredients act locally in the colon and are not absorbed in detectable amounts.

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

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Available formulations

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Dosages

Laxative as preparation for surgery, X-ray or endoscopic examination of the colon
  • Oral
    • 1 year up to 2 years
      • 2.5 mg/dose 1st dose: 10-18 hours prior to procedure
        2nd dose: 4-6 hours prior to procedure.
    • 2 years up to 4 years
      • 5 mg/dose 1st dose: 10-18 hours prior to procedure
        2nd dose: 4-6 hours prior to procedure.
    • 4 years up to 9 years
      • 10 mg/dose 10-18 hours prior to procedure and 5 mg/dose : 4-6 hours prior to procedure

    • 9 years up to 18 years
      • 10 mg/dose 1st dose: 10-18 hours prior to procedure
        2nd dose: 4-6 hours prior to procedure.

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Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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References

  1. Pinfield A. et al, Randomised trial of two pharmacological methods of bowel preparation for day case colonoscopy., Arch Dis Child, 1999, 80(2), 181-3
  2. Ferring BV, SPC Picoprep (RVG 106616) 17-06-2016, www.cbg-meb.nl
  3. MMI, Gelbe Liste I Online Laxoberal® Abführ-Tabletten, 5 mg Tabletten, 06/2018
  4. Ferring, SmPC Picoprep 10mg Pulver zur Herstllung einer Lösung zum Einnehmen (79572.00.00), 06/2016
  5. Sanofi, SmPC Laxoberal 2,5mg Weichkapseln (6926.00.04), 03/2007
  6. Sanofi, SmPC Laxoberal 7,5mg/ml Tropfen zum Einnehmen_Laxoberal 5mg Tabletten (6926.00.01_6926.00.00), 07/2017
  7. Sanofi, SmPC Dulcolax NP Kinder 7,5mg/ml Tropfen zum Einnehmen (22254.00.00), 06/2017
  8. MEDA, SmPC Agiolax Pico 5mg Abführ-Pastillen (6520998.00.00), 04/2015
  9. Krewel Meuselbach, SmPC Regulax Picosulfat 10mg Würfel (6751605.00.01), 08/2013
  10. Krewel Meuselbach, SmPC Regulax 7,23mg/ml Tropfen (6751605.00.00), 03/2013
  11. DAZ.online., Individuell für Kinder: Einige Besonderheiten der paediatrischen Rezeptur. , 05/2018
  12. Breitkreutz J BJ., Paediatric and geriatric drug delivery. Expert opinion on drug delivery, 2007, 4, 37-45
  13. DAZ.online., Individuell für Kinder: Einige Besonderheiten der paediatrischen Rezeptur., 05/2018

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Changes

Changes