- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
No information
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
Available formulations
No information is present at this moment.
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
Dosages
| Inhalation anaesthesia |
|---|
|
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
Renal impaiment in children > 3 months
GFR ≥10 ml/min/1.73m2: Dose adjustment not required.
GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects in children
Delirium on awakening occurs 2-3 times more frequently in children under 6 years of age than in adults.
Convulsions have occurred in particular in children from 2 months. Cases of ventricular arrhythmia have been reported in children with Pompe disease.
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions in children
Limiting the depth of anaesthesia is recommended in children with an increased risk of convulsions. The sevoflurane dose can be optimized by means of an EEG and can be checked for development of convulsive activity.
After administration of sevoflurane has stopped, the patient should be ventilated with 100% oxygen until they are fully awake.
Caution is recommended where there is an increased risk of lengthening of the QTc interval, such as in cases of long QT interval syndrome and in elderly patients with cardiovascular risk factors. Caution is also recommended where there is an increased risk of convulsions, in sleep apnoea (as this may worsen) and in myasthenia gravis (due to the susceptibility to respiratory depression).
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
| Halogenated hydrocarbons | ||
|---|---|---|
| N01AB06 | ||
| Other general anesthetics | ||
|---|---|---|
| N01AX14 | ||
| N01AX10 | ||
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
References
- Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor kinderen, 2007
- Piramal Critical Care B.V. , SmPC Sevoflurane 100% (RVG 106958) 21-06-2023, www.geneesmiddeleninformatiebank.nl
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
Changes
Changes
