Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Tocopherol acetate DL-alpha (vitamin E)

Generic name
Tocopherol acetate DL-alpha (vitamin E)
Brand name
ATC Code
A11HA03

Pharmacokinetics in children

No information

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

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Available formulations

No information is present at this moment.

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Dosages

Supplementation in cystic fibrosis
  • Oral
    • 1 month up to 1 year
      • 50 IU/day in 1 - 3 doses.
Deficiency
  • Oral
    • 1 month up to 18 years
      • 5 - 10 mg/kg/day in 2 doses. Max: 300 mg/day.
      • Vitamin E should preferably be administered in a water-soluble form.

    • 1 month up to 18 years
      [2]
      • 5 - 10 mg/kg/day in 2 doses. Max: 300 mg/day.
      • Vitamin E should preferably be administered in a water-soluble form.

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Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

Necrotizing enterocolitis has been reported in children with low birthweights who received a high dose (200 mg tocopherol acetate daily) as a hyperosmolar solution.

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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References

  1. Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
  2. Kneepkens CMF et al, Werkboek Kindergastro-Enterologie, VU Uitgeverij, 2002, 2e druk
  3. Turck D, et al., ESPEN-ESPGHAN-ECFS guidelines on nutrition care for infants, children, and adults with cystic fibrosis, Clinical Nutrition, 2016, 35, 557-77

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Changes

Changes