- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
In the study by Trope (1979), no chloramphenicol was found in the urine of 5 children (2-8 years) after administration in the eye. There may possibly be absorption after prolonged use.
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
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Available formulations
No information is present at this moment.
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Dosages
| Eye infections (not trachoma) |
|---|
|
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Renal impaiment in children > 3 months
No information available on dose adjustment in renal impairment.
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects in children
Stinging and burning sensation in the eyes, swollen eyelids, irritation, watery eyes.
Using chloramphenicol in the eye does not give levels that are high enough to explain dose-related bone marrow toxicity (aplastic anaemia). [Walker 1998]
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions in children
The use of drops is preferred above the use of monotherapy with salve in children because the drops have a thinning effect. Additionally, the salve is difficult to apply in children because of its very firm consistency.
Grey baby syndrome has been described with systemic administration of chloramphenicol in infants. These effects are unlikely to occur following ocular exposure, as systemic absorption after ocular application is limited.
The eye drops contain boron. This can reduce future fertility. Only use the drops in children < 2 years after careful consideration if no alternative therapy is available.
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| Antibiotics | ||
|---|---|---|
| S01AA26 | ||
| S01AA13 | ||
| S01AA11 | ||
| S01AA24 | ||
| S01AA20 | ||
| S01AA12 | ||
| Antivirals | ||
|---|---|---|
| S01AD03 | ||
| ANTIBIOTICS | ||
|---|---|---|
| S01AA26 | ||
| S01AA13 | ||
| S01AA11 | ||
| S01AA24 | ||
| S01AA20 | ||
| S01AA12 | ||
| ANTIVIRALS | ||
|---|---|---|
| S01AD03 | ||
| Fluoroquinolones | ||
|---|---|---|
| S01AE07 | ||
| S01AE01 | ||
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References
- Rose PW, et al, Chloramphenicol treatment for acute infective conjunctivitis in children in primary care: a randomised double-blind placebo-controlled trial, Lancet., 2005, Jul 2-8;366(9479), 37-43
- Normann EK et al, Treatment of acute neonatal bacterial conjunctivitis: a comparison of fucidic acid to chloramphenicol eye drops, Acta Ophthalmol Scand, 2002, Apr;80(2), 183-7
- Walker S, Lack of evidence for systemic toxicity following topical chloramphenicol use, Eye (Lond)., 1998, 12 ( Pt 5):, 875-9
- Wiholm BE et al, Relation of aplastic anaemia to use of chloramphenicol eye drops in two international case-control studies, BMJ., 1998, Feb 28;316(7132), 666
- Sandström I, Treatment of neonatal conjunctivitis, Arch Ophthalmol, 1987, Jul;105(7), 925-8
- Trope GE, et al, Systemic absorption of topically applied chloramphenicol eyedrops, Br J Ophthalmol, 1979 , Oct;63(10), 690-1
- Lam RF et al, Topical chloramfenicol for eye infections, HKMJ, 2002, 8, 44-7
- Teva Nederland BV, Chlooramfenicol 10 mg/g, oogzalf (RVG 57557) 11-11-2020, www.geneesmiddeleninformatiebank.nl
- Teva Nederland BV, Chlooramfenicol 5 mg/ml , oogdruppels (RVG 01767) 26-09-2017, www.geneesmiddeleninformatiebank.nl
- Trope GE, et al, Systemic absorption of topically applied chloramphenicol eyedrops, Br J Ophthalmol, 1979, Oct;63(10), 690-1
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Changes
Changes
