Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Ammonium chloride

Generic name
Ammonium chloride
Brand name
ATC Code
G04BA01

Pharmacokinetics in children

There is no data known about the pharmacokinetic parameters of ammonium chloride in children.

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

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Available formulations

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Dosages

Metabolic alkalosis
  • Intravenous
    • 1 month up to 18 years

      • Initial dose:
        Dose in mmol NH4Cl = [0.3 l/kg x bodyweight (kg)] x base excess (mmol/l);
        administer 50% of dose over at least 3 hours, then evaluate again.

        Maintenance dose:
        titrate; the normal dose is usually between 50 and 100 mg/kg/day.

         

        • The figure of 0.3 l/kg in the formula is the extracellular bicarbonate and the base excess is determined by laboratory measurement and reported with the arterial blood gases
        • Dilute to 0.2 mmol/ml (max. 0.4 mmol/ml) before administration. Maximum infusion rate 1 mmol/kg/hour.


        There is no evidence regarding the use of ammonium chloride in children for metabolic alkalosis. The dosage is determined using the weight, in the same way as for adults
Acidification of urine
  • Intravenous
    • 1 month up to 18 years
      • 75 mg/kg/day in 4 doses. Max: 6 g/day.
  • Oral
    • 1 month up to 18 years
      • 75 mg/kg/day in 4 doses. Max: 6 g/day.

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Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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Drugs for urinary frequency and incontinence
G04BD04
G04BD04
G04BD06
G04BD08
G04BD07
G04BD09
Drugs used in erectile dysfunction
G04BE03
G04BE08
Other urologicals
G04BX16
OTHER UROLOGICALS
G04BX16

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Reference

  1. NKFK, Expert opinie

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Changes

Changes