- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
No information
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
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Available formulations
No information is present at this moment.
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Dosages
| Aniline or dapsone-induced methaemoglobinaemia |
|---|
|
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Renal impaiment in children > 3 months
- eGFR 60-89 ml/min/1.73m2: dose adjustment not required
- eGFR 30-59 ml/min/1.73m2: 1-2 mg/kg/dose. Repeat if necessary. Maximum cumulative dose: 2 mg/kg/day
- eGFR 15-29 ml/min/1.73m2: single dose of 1 mg/kg/dose. Maximum cumulative dose: 1 mg/kg/day
Infants < 3 months:
- eGFR 15-59 ml/min/1.73m2: use with caution, as no data are available and methylthioninium chloride is excreted primarily renally. Lower maximum cumulative doses (< 0.5 mg/kg body weight) may be considered.
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects in children
The side effects in children are similar to those in adults. Hyperbilirubinaemia is reported in infants.
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions in children
Can cause haemolysis. Children younger than 3 months have lower levels of NADPH-methaemoglobin reductase, making them more susceptible to methaemoglobinaemia caused by high doses of methylthionine.
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| Antidotes | ||
|---|---|---|
| V03AB27 | ||
| V03AB16 | ||
| V03AB24 | ||
| V03AB25 | ||
| V03AB33 | ||
| V03AB15 | ||
| V03AB13 | ||
| V03AB19 | ||
| V03AB14 | ||
| V03AB06 | ||
| V03AB35 | ||
| Iron chelating agents | ||
|---|---|---|
| V03AC03 | ||
| V03AC02 | ||
| V03AC01 | ||
| Drugs for treatment of hyperkalemia and hyperphosphatemia | ||
|---|---|---|
| V03AE07 | ||
| V03AE01 | ||
| V03AE02 | ||
| V03AE01 | ||
| Detoxifying agents for antineoplastic treatment | ||
|---|---|---|
| V03AF03 | ||
| V03AF01 | ||
| V03AF07 | ||
| Drugs for treatment of hypoglycemia | ||
|---|---|---|
| V03AH01 | ||
| Other therapeutic products | ||
|---|---|---|
| V03AX03 | ||
| DETOXIFYING AGENTS FOR ANTINEOPLASTIC TREATMENT | ||
|---|---|---|
| V03AF03 | ||
| V03AF01 | ||
| V03AF07 | ||
| OTHER THERAPEUTIC PRODUCTS | ||
|---|---|---|
| V03AX03 | ||
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References
- Driscoll W, et al, Effect of methylene blue on refractory neonatal hypotension, J Pediatr, 1996, Dec;129(6), 904-8
- PROVEPHARM SAS, SmPC Methylthionine Proveblue (EU/1/11/682) REV 25; 15-12-2022, https://www.ema.europa.eu
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Changes
Changes
